Abstract: Background: Incidence of pregnancy induced hypertension is increasing and it is most common medical complication of pregnancy. Measurement of the level of hs CRP, serum lipid profile can be used as predictor of the disease. The present study is aimed to evaluate the relationship of High-Sensitivity serum C-reactive protein and lipid profile in women with pregnancy induced hypertension.
Methods: This was a case-control study among purposively selected pregnant women attending inpatient and outpatient department of Obstetrics and Gynecology, Sir Salimullah Medical College and Mitford Hospital, Dhaka from March 2019 to February 2020. A total 120 singleton pregnant women between 18-35 years of age were included in this study after 20 weeks of gestation. Among them 60 diagnosed pregnancy-induced hypertension and rest of the 60 normotensive pregnant women were considered as case and control respectively. After taking consent, data were collected from patients on variables of interest using the predesigned semi-structured questionnaire by interview, observation, relevant clinical examination and laboratory investigation of the participants. Their serum hs-CRP and serum lipid profile level were measured. Analysis was done using the analytic software SPSS v26.0.
Results: Among the case 30.0% with serum hs-CRP level ≥ 9.66 mg/dl had 3.24 times more chance to develop pregnancy induced hypertension. Mean serum hs-CRP level, total cholesterol, LDL and triglyceride was 6.98±4.21, 261.13±68.62, 183.76±66.51 285.98±125.61 respectively among cases compared to 5.26±2.72, 220.46±54.16, 121.90±33.36, 189.03±64.38 among control and all the parameters were significantly high in cases. There was significant positive correlation found with increased systolic blood pressure, diastolic blood pressure and higher level of serum hs-CRP level, total cholesterol, LDL and triglyceride.
Conclusion: HS-CRP, serum total cholesterol, serum LDL, serum triglycerides were significantly higher among women with pregnancy induced hypertension. Odds Ratio of developing Pregnancy Induced Hypertension is also significantly more with patient having dyslipidemia and high hs-CRP. Thus, the measurement of the level of hs-CRP, serum total cholesterol, serum LDL, serum triglycerides can be used as predictor of the disease.
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